NCI Definition: A germinal center-derived B-cell lymphoma that affects predominantly children and young adults. It is characterized by the presence of strong IRF4 expression and IRF4 translocation, BCL2 expression, and the absence of t(14;18)(q32;q21). It affects the Waldeyer's ring, head and neck lymph nodes, and the intestine. Morphologically it is characterized by the presence of diffuse and grade 3 follicular areas. [1]

Significant Genes in Large B-Cell Lymphoma with IRF4 Rearrangement


BCL2 +

BCL6 +

IRF4 +


Disease Details

LBCL with IRF4 Rearrangement
Mature B-Cell Non-Hodgkin Lymphoma
OncoTree Name
Large B-Cell Lymphoma with IRF4 Rearrangement
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.