Diseases /
Large Cell Lung Carcinoma, Clear Cell Variant
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Associated Genetic Biomarkers
Overview
NCI Definition: A morphologic variant of large cell lung carcinoma characterized by a predominance of clear cells that may or may not contain glycogen. [1]
Large cell lung carcinoma, clear cell variants most frequently harbor alterations in TP53 and STK11 [2].
TP53 c.217-c.1178 Missense, TP53 R283P, TP53 Mutation, TP53 Missense, and TP53 Exon 8 Mutation are the most common alterations in large cell lung carcinoma, clear cell variant [2].
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.