Overview

NCI Definition: A morphologic variant of large cell lung carcinoma characterized by a predominance of clear cells that may or may not contain glycogen. [1]

Large cell lung carcinoma, clear cell variants most frequently harbor alterations in TP53 and STK11 [2].

Most Commonly Altered Genes in Large Cell Lung Carcinoma, Clear Cell Variant

TP53 c.217-c.1178 Missense, TP53 R283P, TP53 Mutation, TP53 Missense, and TP53 Exon 8 Mutation are the most common alterations in large cell lung carcinoma, clear cell variant [2].

Top Alterations in Large Cell Lung Carcinoma, Clear Cell Variant

Disease Details

Synonyms
Clear Cell Carcinoma of the Lung, Large Cell Type, Clear Cell Lung Carcinoma, Large Cell Type, Clear Cell Carcinoma of Lung, Large Cell Type, Lung Large Cell Carcinoma, Clear Cell Variant
Parent(s)
Large Cell Lung Carcinoma
OncoTree Name
Clear Cell Carcinoma of the Lung
OncoTree Code
CCLC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.