NCI Definition: A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. The vast majority of cases are positive for neuron-specific enolase. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas. [1]

Large cell neuroendocrine carcinomas most frequently harbor alterations in TP53, STK11, RB1, KRAS, and KEAP1 [2].

Most Commonly Altered Genes in Large Cell Neuroendocrine Carcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KRAS Mutation, and TP53 Nonsense are the most common alterations in large cell neuroendocrine carcinoma [2].

Top Alterations in Large Cell Neuroendocrine Carcinoma

Disease Details

Large Cell NEC, Large-cell neuroendocrine carcinoma
Neuroendocrine Carcinoma
Cervical Large Cell Neuroendocrine Carcinoma, Vaginal Large Cell Neuroendocrine Carcinoma, Thymic Large Cell Neuroendocrine Carcinoma, Ovarian Large Cell Neuroendocrine Carcinoma, Large Cell Lung Neuroendocrine Carcinoma, and Breast Large Cell Neuroendocrine Carcinoma
OncoTree Name
Large Cell Neuroendocrine Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.