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Large Cell Neuroendocrine Carcinoma

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Overview

NCI Definition: A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. The vast majority of cases are positive for neuron-specific enolase. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas. [1]

Clinical Trials

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Disease Details

Synonyms
Large Cell NEC, Large-cell neuroendocrine carcinoma
Parent(s)
Neuroendocrine Carcinoma
Children
Thymic Large Cell Neuroendocrine Carcinoma, Large Cell Lung Neuroendocrine Carcinoma, Ovarian Large Cell Neuroendocrine Carcinoma, Cervical Large Cell Neuroendocrine Carcinoma, Breast Large Cell Neuroendocrine Carcinoma, and Vaginal Large Cell Neuroendocrine Carcinoma
OncoTree Name
Large Cell Neuroendocrine Carcinoma
OncoTree Code
LUNE

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.