Overview

NCI Definition: Carcinoma that arises from the laryngeal epithelium. More than 90% of laryngeal carcinomas are squamous cell carcinomas. The remainder are adenoid cystic carcinomas, mucoepidermoid carcinomas and carcinomas with neuroendocrine differentiation. [1]

Laryngeal carcinomas most frequently harbor alterations in TP53, CDKN2A, PIK3CA, KMT2D, and CCND1 [2].

Most Commonly Altered Genes in Laryngeal Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KMT2D Mutation, and PIK3CA Mutation are the most common alterations in laryngeal carcinoma [2].

Top Alterations in Laryngeal Carcinoma

Significant Genes in Laryngeal Carcinoma

ERBB2 +

Disease Details

Synonyms
Laryngeal Cancer, Cancer of Larynx, Cancer of the Larynx, Larynx Carcinoma, Carcinoma of Larynx, Carcinoma of the Larynx
Parent(s)
Malignant Laryngeal Neoplasm
Children
Laryngeal Squamous Cell Carcinoma, Laryngeal Small Cell Carcinoma, Subglottic Carcinoma, Supraglottic Carcinoma, Glottis Carcinoma, Laryngeal Adenoid Cystic Carcinoma, and Laryngeal Mucoepidermoid Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.