Overview

NCI Definition: A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years. [1]

Leukemias most frequently harbor alterations in DNMT3A, ASXL1, TET2, ETV6, and NPM1 [2].

Most Commonly Altered Genes in Leukemia

ASXL1 Mutation, DNMT3A Mutation, TET2 Mutation, NPM1 Mutation, and ETV6 Mutation are the most common alterations in leukemia [2].

Top Alterations in Leukemia

Significant Genes in Leukemia

ERBB2 +

IDH1 +

IDH2 +

TP53 +

Disease Details

Synonyms
LEUKEMIA, MALIGNANT, Leukemias, Leukemia NOS, Leukemias, General, Leukemia, Disease, Leukemia, NOS, Blood (Leukemia)
Parent(s)
Hematopoietic and Lymphoid Malignancy
Children
Mast Cell Leukemia, Aleukemic Leukemia, Childhood Leukemia, Central Nervous System Leukemia, Precursor T-Cell Lymphoblastic Lymphoma/Leukemia, Acute Leukemia, Monocytic Leukemia, Splenic Manifestation of Leukemia, Juvenile Myelomonocytic Leukemia, Chronic Myelomonocytic Leukemia, Chronic Leukemia, Myeloid Leukemia, Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative, and T-cell Leukemia
OncoTree Name
Leukemia
OncoTree Code
LEUK

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.