Overview

NCI Definition: A usually painless malignant tumor that arises from adipose tissue. Microscopically, it may contain a spectrum of neoplastic adipocytes ranging from lipoblasts to pleomorphic malignant adipocytes. Morphologic variants include: well differentiated, dedifferentiated, pleomorphic, and myxoid liposarcoma. The metastatic potential is higher in less differentiated tumors. [1]

Liposarcomas most frequently harbor alterations in MDM2, CDK4, GLI1, TP53, and TNFAIP3 [2].

Most Commonly Altered Genes in Liposarcoma

MDM2 Amplification, CDK4 Amplification, GLI1 Amplification, TNFAIP3 Amplification, and TP53 Mutation are the most common alterations in liposarcoma [2].

Top Alterations in Liposarcoma

Biomarker-Directed Therapies

Significant Genes in Liposarcoma

AKT1 +

AKT2 +

AKT3 +

CCND1 +

CDK4 +

CRKL +

DDIT3 +

EGFR +

ERBB2 +

IRS2 +

KIT +

MET +

MTOR +

MYCN +

PDGFRA +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PTEN +

RICTOR +

RNF43 +

RPTOR +

TSC1 +

TSC2 +

Disease Details

Synonyms
Soft tissue liposarcoma, LIPOSARCOMA, MALIGNANT, Liposarcoma Not Otherwise Specified
Parent(s)
Sarcoma
Children
Dedifferentiated Liposarcoma, Breast Liposarcoma, Fibroblastic Liposarcoma, Vulvar Liposarcoma, Gastric Liposarcoma, Bone Liposarcoma, Kidney Liposarcoma, Mixed Liposarcoma, Laryngeal Liposarcoma, Intracranial Liposarcoma, Esophageal Liposarcoma, Round Cell Liposarcoma, Adult Liposarcoma, Cutaneous Liposarcoma, Ovarian Liposarcoma, Pleomorphic Liposarcoma, Myxoid Liposarcoma, Mediastinal Liposarcoma, Childhood Liposarcoma, Well Differentiated Liposarcoma, and Atypical Lipomatous Tumor
OncoTree Name
Liposarcoma
OncoTree Code
LIPO

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.