Overview

NCI Definition: A usually painless malignant tumor that arises from adipose tissue. Microscopically, it may contain a spectrum of neoplastic adipocytes ranging from lipoblasts to pleomorphic malignant adipocytes. Morphologic variants include: well differentiated, dedifferentiated, pleomorphic, and myxoid liposarcoma. The metastatic potential is higher in less differentiated tumors. [1]

Biomarker-Directed Therapies

Significant Genes in Liposarcoma

AKT1 +

AKT2 +

AKT3 +

CCND1 +

CDK4 +

CRKL +

DDIT3 +

ERBB2 +

MDM2 +

MTOR +

MYCN +

PDGFRA +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PTEN +

RICTOR +

RPTOR +

TSC1 +

TSC2 +

Disease Details

Synonyms
LIPOSARCOMA, MALIGNANT, Soft tissue liposarcoma, Liposarcoma Not Otherwise Specified
Parent(s)
Sarcoma
Children
Round Cell Liposarcoma, Kidney Liposarcoma, Childhood Liposarcoma, Breast Liposarcoma, Fibroblastic Liposarcoma, Laryngeal Liposarcoma, Bone Liposarcoma, Dedifferentiated Liposarcoma, Vulvar Liposarcoma, Myxoid Liposarcoma, Esophageal Liposarcoma, Ovarian Liposarcoma, Atypical Lipomatous Tumor, Intracranial Liposarcoma, Mediastinal Liposarcoma, Well Differentiated Liposarcoma, Gastric Liposarcoma, Adult Liposarcoma, Cutaneous Liposarcoma, Mixed Liposarcoma, and Pleomorphic Liposarcoma
OncoTree Name
Liposarcoma
OncoTree Code
LIPO

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.