Overview

NCI Definition: A carcinoma that arises from the hepatocytes or intrahepatic bile ducts. The main subtypes are hepatocellular carcinoma (hepatoma) and cholangiocarcinoma. [1]

Liver and intrahepatic bile duct carcinomas most frequently harbor alterations in TP53, ARID1A, IDH1, CTNNB1, and BAP1 [2].

Most Commonly Altered Genes in Liver and Intrahepatic Bile Duct Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, IDH1 Mutation, and IDH1 Codon 132 Missense are the most common alterations in liver and intrahepatic bile duct carcinoma [2].

Top Alterations in Liver and Intrahepatic Bile Duct Carcinoma

Disease Details

Synonyms
Hepatic Cancer, Liver and Intrahepatic Biliary Tract Cancer, Cancer of Liver and Intrahepatic Biliary Tract, Cancer of the Liver, Primary Liver Carcinoma, Cancer of Liver, Cancer of the Liver and Intrahepatic Biliary Tract, Liver and Intrahepatic Biliary Tract Carcinoma, Liver and Intrahepatic Bile Duct Cancer, Liver/hepatobiliary cancer, Liver and hepatobiliary cancer, NOS, Liver Cancer
Parent(s)
Primary Malignant Liver Neoplasm
Children
Combined Hepatocellular Carcinoma and Cholangiocarcinoma, Intrahepatic Cholangiocarcinoma, Liver Undifferentiated Carcinoma, and Hepatocellular Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.