Associated Genetic Biomarkers

Overview

Liver neoplasms most frequently harbor alterations in TP53, CTNNB1, ARID1A, IDH1, and BAP1 [2].

Most Commonly Altered Genes in Liver Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, CTNNB1 Mutation, and IDH1 Mutation are the most common alterations in liver neoplasm [2].

Top Alterations in Liver Neoplasm

Disease Details

Parent(s)
Liver and Intrahepatic Bile Duct Neoplasm
Children
Liver Lipoma, Primary Malignant Liver Neoplasm, Liver Inflammatory Myofibroblastic Tumor, Liver Hemangioma, Liver Leiomyoma, Liver Angiomyolipoma, and Liver Solitary Fibrous Tumor

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.