Lobular Breast Carcinoma
Associated Genetic Biomarkers
NCI Definition: An adenocarcinoma of the breast arising from the lobules. This is a relatively uncommon carcinoma, represents approximately 10% of the breast adenocarcinomas and is often bilateral or multifocal. 
Lobular breast carcinomas most frequently harbor alterations in CDH1, PIK3CA, TP53, ERBB2, and CCND1 .
CDH1 Mutation, PIK3CA Mutation (somatic), PIK3CA Mutation, PIK3CA H1047R, and TP53 Mutation are the most common alterations in lobular breast carcinoma .
There are 2 clinical trials for lobular breast carcinoma, of which 2 are open and 0 are completed or closed. Of the trials that contain lobular breast carcinoma as an inclusion criterion, 1 is phase 1/phase 2 (1 open) and 1 is phase 2 (1 open).
ERBB2 is the most frequent gene inclusion criterion for lobular breast carcinoma clinical trials .
Partial breast irradiation, crizotinib, and fulvestrant are the most common interventions in lobular breast carcinoma clinical trials.
Significant Genes in Lobular Breast Carcinoma
ERBB2 is mutated in 12.13% of lobular breast carcinoma patients .
ERBB2 is an inclusion eligibility criterion in 2 clinical trials for lobular breast carcinoma, of which 2 are open and 0 are closed. Of the trials that contain ERBB2 status and lobular breast carcinoma as inclusion criteria, 1 is phase 1/phase 2 (1 open) and 1 is phase 2 (1 open) .
Partial breast irradiation, crizotinib, and fulvestrant are the most frequent therapies in lobular breast carcinoma trials with ERBB2 mutations as inclusion criteria .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.