NCI Definition: An adenocarcinoma of the breast arising from the lobules. This is a relatively uncommon carcinoma, represents approximately 10% of the breast adenocarcinomas and is often bilateral or multifocal. [1]

Lobular breast carcinomas most frequently harbor alterations in CDH1, PIK3CA, TP53, CCND1, and ERBB2 [2].

Most Commonly Altered Genes in Lobular Breast Carcinoma

PIK3CA Mutation, CDH1fs, CDH1 Mutation, PIK3CA Codon 1047 Missense, and PIK3CA H1047R are the most common alterations in lobular breast carcinoma [2].

Top Alterations in Lobular Breast Carcinoma

Significant Genes in Lobular Breast Carcinoma

CDH1 +

Disease Details

Lobular Carcinoma of the Breast, Lobular Carcinoma, Lobular Adenocarcinoma, Lobular Carcinoma of Breast
Breast Adenocarcinoma
Breast Invasive Lobular Carcinoma and Breast Lobular Carcinoma In Situ


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.