Low Grade Astrocytic Tumor
Associated Genetic Biomarkers
NCI Definition: A grade I or grade II astrocytic tumor. This category includes pilocytic astrocytoma (grade I), subependymal giant cell astrocytoma (grade I), and diffuse astrocytoma (grade II). 
Low grade astrocytic tumors most frequently harbor alterations in BRAF, KIAA1549, NF1, FGFR1, and CIC .
BRAF Fusion, KIAA1549-BRAF Fusion, BRAF-KIAA1549 Fusion, KIAA1549 Fusion, and BRAF Mutation are the most common alterations in low grade astrocytic tumor .
There is 1 clinical trial for low grade astrocytic tumor, of which 1 is open and 0 are completed or closed. Of the trial that contains low grade astrocytic tumor as an inclusion criterion, 1 is phase 3 (1 open).
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.