Overview

NCI Definition: A grade I or grade II astrocytic tumor. This category includes pilocytic astrocytoma (grade I), subependymal giant cell astrocytoma (grade I), and diffuse astrocytoma (grade II). [1]

Low grade astrocytic tumors most frequently harbor alterations in BRAF, KIAA1549, NF1, FGFR1, and CIC [2].

BRAF Fusion, KIAA1549-BRAF Fusion, BRAF-KIAA1549 Fusion, KIAA1549 Fusion, and BRAF Mutation are the most common alterations in low grade astrocytic tumor [2].

Disease Details

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.