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Lung Carcinoid Tumor

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Associated Genetic Biomarkers

Overview

NCI Definition: A neuroendocrine neoplasm that arises from the lung. It is characterized by the presence of uniform polygonal cells with small or moderate amount of cytoplasm and inconspicuous nucleoli. The cells are usually arranged in organoid and trabecular patterns. It is classified as typical or atypical carcinoid tumor based on the number of mitotic figures and the absence or presence of necrosis. Atypical carcinoid tumors have a worse prognosis. [1]

Lung carcinoid tumors most frequently harbor alterations in MEN1, ARID1A, EIF1AX, ATM, and CCND1 [2].

Most Commonly Altered Genes in Lung Carcinoid Tumor

EIF1AX Mutation, MEN1 Mutation, ATM Mutation, ARID1A Nonsense, and ARID1A Mutation are the most common alterations in lung carcinoid tumor [2].

Top Alterations in Lung Carcinoid Tumor

Clinical Trials

View Clinical Trials for Lung Carcinoid Tumor

Disease Details

Synonyms
Pulmonary Carcinoid Tumor, Lung Neuroendocrine Tumor, Carcinoid Tumor of the Lung, Carcinoid Tumor of Lung
Parent(s)
Neuroendocrine Tumor
Children
Lung Atypical Carcinoid Tumor and Lung Typical Carcinoid Tumor
OncoTree Name
Lung Carcinoid
OncoTree Code
LUCA

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.