Overview

NCI Definition: A low, intermediate, or high grade malignant neoplasm with neuroendocrine differentiation that arises from the lung. This category includes typical carcinoid tumor, atypical carcinoid tumor, small cell carcinoma, large cell neuroendocrine carcinoma, and combined carcinoma. [1]

Lung neuroendocrine neoplasms most frequently harbor alterations in TP53, RB1, KMT2D, CREBBP, and NOTCH1 [2].

Most Commonly Altered Genes in Lung Neuroendocrine Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in lung neuroendocrine neoplasm [2].

Top Alterations in Lung Neuroendocrine Neoplasm

Disease Details

Synonyms
Neuroendocrine Neoplasm of the Lung, Pulmonary Neuroendocrine Neoplasm, Neuroendocrine Neoplasm of Lung
Parent(s)
Neuroendocrine Neoplasm
Children
Combined Large Cell Lung Neuroendocrine Carcinoma, Large Cell Lung Neuroendocrine Carcinoma, Lung Carcinoid Tumor, and Small Cell Lung Carcinoma
OncoTree Name
Lung Neuroendocrine Tumor
OncoTree Code
LNET

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.