Overview

NCI Definition: A low, intermediate, or high grade malignant neoplasm with neuroendocrine differentiation that arises from the lung. This category includes typical carcinoid tumor, atypical carcinoid tumor, small cell carcinoma, large cell neuroendocrine carcinoma, and combined carcinoma. [1]

Lung neuroendocrine neoplasms most frequently harbor alterations in TP53, RB1, KMT2D, CREBBP, and NOTCH1 [2].

Most Commonly Altered Genes in Lung Neuroendocrine Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, RB1 Mutation, and TP53 Exon 5 Mutation are the most common alterations in lung neuroendocrine neoplasm [2].

Top Alterations in Lung Neuroendocrine Neoplasm

Significant Genes in Lung Neuroendocrine Neoplasm

EGFR +

Disease Details

Synonyms
Pulmonary Neuroendocrine Neoplasm, Neuroendocrine Neoplasm of the Lung, Neuroendocrine Neoplasm of Lung
Parent(s)
Neuroendocrine Neoplasm
Children
Lung Carcinoid Tumor and Lung Neuroendocrine Carcinoma
OncoTree Name
Lung Neuroendocrine Tumor
OncoTree Code
LNET

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.