Associated Genetic Biomarkers

Overview

NCI Definition: A neoplasm composed of a lymphocytic cell population which is usually malignant (clonal) by molecular genetic and/or immunophenotypic analysis. Lymphocytic neoplasms include Hodgkin and non-Hodgkin lymphomas, acute and chronic lymphocytic leukemias, and plasma cell neoplasms. [1]

Lymphocytic neoplasms most frequently harbor alterations in KMT2D, TP53, CREBBP, BCL2, and TET2 [2].

Most Commonly Altered Genes in Lymphocytic Neoplasm

TP53 Mutation, CREBBP Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, and KMT2D Mutation are the most common alterations in lymphocytic neoplasm [2].

Top Alterations in Lymphocytic Neoplasm

Significant Genes in Lymphocytic Neoplasm

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

Disease Details

Synonyms
Lymphocytic and Plasma Cell Tumor, Lymphoid Tumor, Lymphocytic and Plasmacytic Neoplasm, Lymphocytic Tumor, Lymphocytic and Plasma Cell Tumour, Lymphoid and Plasma Cell Tumour, Lymphoid and Plasmacytic Tumor, Lymphoid and Plasma Cell Tumor, Lymphocytic and Plasma Cell Neoplasm, Lymphoid Neoplasm, Lymphoid and Plasmacytic Tumour, Lymphoid and Plasmacytic Neoplasm
Parent(s)
Lymphoproliferative Disorder
Children
B-Cell Neoplasm, T-Cell and NK-Cell Neoplasm, Angiocentric Immunoproliferative Lesion, Lymphoma, and Lymphoid Leukemia
OncoTree Name
Lymphoid Neoplasm
OncoTree Code
LNM

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.