Associated Genetic Biomarkers

Overview

NCI Definition: A neoplasm composed of a lymphocytic cell population which is usually malignant (clonal) by molecular genetic and/or immunophenotypic analysis. Lymphocytic neoplasms include Hodgkin and non-Hodgkin lymphomas, acute and chronic lymphocytic leukemias, and plasma cell neoplasms. [1]

Lymphocytic neoplasms most frequently harbor alterations in KMT2D, CREBBP, TP53, BCL2, and TET2 [2].

Most Commonly Altered Genes in Lymphocytic Neoplasm

KMT2D Mutation, CREBBP Mutation, TP53 Mutation, TP53 c.217-c.1178 Missense, and TP53 Missense are the most common alterations in lymphocytic neoplasm [2].

Top Alterations in Lymphocytic Neoplasm

Significant Genes in Lymphocytic Neoplasm

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

Disease Details

Synonyms
Lymphocytic and Plasma Cell Tumor, Lymphocytic Tumor, Lymphoid and Plasma Cell Tumor, Lymphoid and Plasmacytic Neoplasm, Lymphoid and Plasmacytic Tumor, Lymphocytic and Plasma Cell Tumour, Lymphocytic and Plasma Cell Neoplasm, Lymphoid Neoplasm, Lymphoid and Plasmacytic Tumour, Lymphoid and Plasma Cell Tumour, Lymphoid Tumor, Lymphocytic and Plasmacytic Neoplasm
Parent(s)
Hematopoietic and Lymphoid Cell Neoplasm
Children
Lymphoid Leukemia, T-Cell and NK-Cell Neoplasm, Angiocentric Immunoproliferative Lesion, Lymphoma, and B-Cell Neoplasm
OncoTree Name
Lymphoid Neoplasm
OncoTree Code
LNM

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.