Overview

NCI Definition: A malignant tumor that arises from the bone. It is characterized by the presence of an area of high grade sarcoma in an otherwise typical giant cell tumor (primary malignancy in giant cell tumor), or the presence of sarcoma in which the pre-existing giant cell tumor may or may not be apparent (secondary malignancy in giant cell tumor). [1]

Disease Details

Synonyms
Dedifferentiated Giant Cell Tumor, OSTEOCLASTOMA, MALIGNANT, Giant Cell Bone Sarcoma, Giant Cell Sarcoma of the Bone, Giant Cell Sarcoma of Bone, Malignancy in Giant Cell Tumor of the Bone, Malignant Giant Cell Tumor of Bone
Parent(s)
Malignant Osteoclastic Giant Cell-Rich Tumor of Bone

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.