Malignancy in Giant Cell Tumor of Bone
NCI Definition: A malignant tumor that arises from the bone. It is characterized by the presence of an area of high grade sarcoma in an otherwise typical giant cell tumor (primary malignancy in giant cell tumor), or the presence of sarcoma in which the pre-existing giant cell tumor may or may not be apparent (secondary malignancy in giant cell tumor). 
There is 1 clinical trial for malignancy in giant cell tumor of bone, of which 1 is open and 0 are completed or closed. Of the trial that contains malignancy in giant cell tumor of bone as an inclusion criterion, 1 is phase 2 (1 open).
Denosumab is the most common intervention in malignancy in giant cell tumor of bone clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.