NCI Definition: A primary or metastatic malignant neoplasm affecting the adrenal cortex. [1]

Malignant adrenal cortex neoplasms most frequently harbor alterations in TP53, CTNNB1, CDKN2A, ATRX, and RB1 [2].

Most Commonly Altered Genes in Malignant Adrenal Cortex Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, CTNNB1 Mutation, and CDKN2A Loss are the most common alterations in malignant adrenal cortex neoplasm [2].

Top Alterations in Malignant Adrenal Cortex Neoplasm

Disease Details

Adrenal Cortex Cancer
Adrenal Gland Cancer
Adrenal Cortex Carcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.