Overview

NCI Definition: A primary or metastatic malignant neoplasm affecting the adrenal cortex. [1]

Malignant adrenal cortex neoplasms most frequently harbor alterations in TP53, CTNNB1, CDKN2A, ATRX, and RB1 [2].

Most Commonly Altered Genes in Malignant Adrenal Cortex Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, CTNNB1 Mutation, and CDKN2A Loss are the most common alterations in malignant adrenal cortex neoplasm [2].

Top Alterations in Malignant Adrenal Cortex Neoplasm

Disease Details

Synonyms
Adrenal Cortex Cancer
Parent(s)
Adrenal Gland Cancer
Children
Adrenal Cortex Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.