Overview

NCI Definition: A primary or metastatic malignant neoplasm involving the bladder. [1]

Malignant bladder neoplasms most frequently harbor alterations in TP53, KMT2D, KDM6A, FGFR3, and ARID1A [2].

Most Commonly Altered Genes in Malignant Bladder Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KMT2D Mutation, and KDM6A Mutation are the most common alterations in malignant bladder neoplasm [2].

Top Alterations in Malignant Bladder Neoplasm

Disease Details

Synonyms
Malignant Tumor, Urinary Bladder, Malignant Tumor of the Urinary Bladder, Malignant Urinary Bladder Neoplasm, Malignant Tumor of the Bladder, Malignant Urinary Bladder Tumor, Malignant Neoplasm, Urinary Bladder, Malignant Neoplasm of Bladder, Malignant Tumor of Urinary Bladder, Malignant Neoplasm of the Bladder, Malignant Neoplasm of Urinary Bladder, Malignant Tumor of Bladder, Malignant Bladder Tumor, Malignant Neoplasm of the Urinary Bladder, Urinary Bladder Malignant Neoplasm, Malignant Neoplasm, Bladder, Urinary Bladder Malignant Tumor
Parent(s)
Malignant Urinary System Neoplasm
Children
Bladder Lymphoma, Bladder Sarcoma, and Bladder Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.