NCI Definition: A primary or metastatic malignant neoplasm involving the bladder. [1]

Malignant bladder neoplasms most frequently harbor alterations in TP53, KDM6A, KMT2D, FGFR3, and ARID1A [2].

Most Commonly Altered Genes in Malignant Bladder Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, FGFR3 Mutation, and KMT2D Mutation are the most common alterations in malignant bladder neoplasm [2].

Top Alterations in Malignant Bladder Neoplasm

Disease Details

Malignant Tumor of Urinary Bladder, Malignant Tumor, Urinary Bladder, Malignant Neoplasm of Bladder, Malignant Tumor of the Bladder, Malignant Neoplasm, Bladder, Malignant Tumor of the Urinary Bladder, Malignant Neoplasm of Urinary Bladder, Urinary Bladder Malignant Tumor, Malignant Bladder Tumor, Malignant Neoplasm of the Urinary Bladder, Malignant Neoplasm, Urinary Bladder, Malignant Tumor of Bladder, Malignant Urinary Bladder Neoplasm, Malignant Urinary Bladder Tumor, Urinary Bladder Malignant Neoplasm, Malignant Neoplasm of the Bladder
Malignant Urinary System Neoplasm
Bladder Malignant PEComa, Bladder Sarcoma, Bladder Lymphoma, and Bladder Carcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.