Overview

NCI Definition: Malignant neoplasms that either originate from the bone marrow (e.g. myeloid leukemias) or involve the bone marrow as secondary-metastatic tumors (e.g. metastatic carcinomas to the bone marrow). --2003 [1]

Malignant bone marrow neoplasms most frequently harbor alterations in ASXL1, ETV6, TET2, DNMT3A, and TP53 [2].

Most Commonly Altered Genes in Malignant Bone Marrow Neoplasm

ASXL1 Mutation, ETV6 Mutation, TET2 Mutation, ETV6 Frameshift, and ASXL1 Frameshift are the most common alterations in malignant bone marrow neoplasm [2].

Top Alterations in Malignant Bone Marrow Neoplasm

Significant Genes in Malignant Bone Marrow Neoplasm

ERBB2 +

Disease Details

Parent(s)
Bone Marrow Neoplasm
Children
Myelodysplastic/Myeloproliferative Neoplasm, Myeloid Leukemia, Myeloproliferative Neoplasm, Megakaryocytic Neoplasm, Therapy-Related Myeloid Neoplasm, and Myelodysplastic Syndromes

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.