Overview

NCI Definition: Malignant neoplasms that either originate from the bone marrow (e.g. myeloid leukemias) or involve the bone marrow as secondary-metastatic tumors (e.g. metastatic carcinomas to the bone marrow). --2003 [1]

Malignant bone marrow neoplasms most frequently harbor alterations in TET2, ASXL1, DNMT3A, TP53, and JAK2 [2].

Most Commonly Altered Genes in Malignant Bone Marrow Neoplasm

JAK2 Mutation, JAK2 V617F, JAK2 Exon 14 Mutation, DNMT3A Mutation, and TP53 Mutation are the most common alterations in malignant bone marrow neoplasm [2].

Top Alterations in Malignant Bone Marrow Neoplasm

Significant Genes in Malignant Bone Marrow Neoplasm

ERBB2 +

Disease Details

Parent(s)
Hematopoietic and Lymphoid Malignancy
Children
Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasm, Megakaryocytic Neoplasm, Myeloproliferative Neoplasm, Myeloid Leukemia, and Therapy-Related Myeloid Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.