NCI Definition: A primary or metastatic malignant neoplasm affecting the brain. [1]

Malignant brain neoplasms most frequently harbor alterations in TP53, PTCH1, KMT2D, CTNNB1, and FBXW7 [2].

Most Commonly Altered Genes in Malignant Brain Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KMT2D Mutation, and CTNNB1 Mutation are the most common alterations in malignant brain neoplasm [2].

Top Alterations in Malignant Brain Neoplasm

Significant Genes in Malignant Brain Neoplasm

MLH1 +

MSH2 +

MSH6 +

NF1 +

PMS2 +

Disease Details

Brain Cancer, Brain Neoplasms, Malignant, Malignant Tumor of the Brain, Malignant Brain Tumor, Cancer of the Brain, Malignant Tumor of Brain, Malignant Neoplasm of Brain, Malignant Neoplasm of the Brain, Cancer of Brain
Malignant Intracranial Neoplasm
Brain Germinoma, Malignant Primary Brain Neoplasm, Gliomatosis Cerebri, Malignant Choroid Plexus Neoplasm, Brain Sarcoma, Malignant Supratentorial Neoplasm, Malignant Infratentorial Neoplasm, and Metastatic Malignant Neoplasm in the Brain


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.