Overview

NCI Definition: A primary or metastatic malignant neoplasm affecting the brain. [1]

Malignant brain neoplasms most frequently harbor alterations in TP53, NRAS, MTOR, FBXW7, and PTEN [2].

Most Commonly Altered Genes in Malignant Brain Neoplasm

TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, TP53 Mutation, and TP53 Missense are the most common alterations in malignant brain neoplasm [2].

Top Alterations in Malignant Brain Neoplasm

Significant Genes in Malignant Brain Neoplasm

EGFR +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

NF1 +

PMS1 +

PMS2 +

Disease Details

Synonyms
Cancer of the Brain, Cancer of Brain, Brain Cancer, Malignant Neoplasm of Brain, Brain Neoplasms, Malignant, Malignant Neoplasm of the Brain, Malignant Brain Tumor, Malignant Tumor of the Brain, Malignant Tumor of Brain
Parent(s)
Malignant Intracranial Neoplasm
Children
Malignant Primary Brain Neoplasm, Brain Sarcoma, Gliomatosis Cerebri, Brain Germinoma, Malignant Choroid Plexus Neoplasm, Malignant Supratentorial Neoplasm, and Malignant Infratentorial Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.