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Malignant Brain Neoplasm
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Associated Genetic Biomarkers
Overview
NCI Definition: A primary or metastatic malignant neoplasm affecting the brain. [1]
Malignant brain neoplasms most frequently harbor alterations in TP53, NRAS, MTOR, FBXW7, and PTEN [2].
TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, TP53 Mutation, and TP53 Missense are the most common alterations in malignant brain neoplasm [2].
Clinical Trials
Significant Genes in Malignant Brain Neoplasm
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.