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Malignant Central Nervous System Germ Cell Tumor

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Associated Genetic Biomarkers

Overview

NCI Definition: A germ cell tumor that affects the central nervous system, characterized by the presence of malignant morphologic characteristics. Representative examples include choriocarcinoma, embryonal carcinoma, and germinoma. [1]

Clinical Trials

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Significant Genes in Malignant Central Nervous System Germ Cell Tumor

H3F3A +

Disease Details

Synonyms
Malignant Central Nervous System Germ Cell Neoplasm
Parent(s)
Malignant Extragonadal Germ Cell Tumor
Children
Central Nervous System Embryonal Carcinoma, Central Nervous System Teratoma with Malignant Transformation, Malignant Intracranial Germ Cell Tumor, Central Nervous System Choriocarcinoma, Central Nervous System Yolk Sac Tumor, Central Nervous System Germinoma, Central Nervous System Immature Teratoma, and Central Nervous System Mixed Germ Cell Tumor

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.