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Malignant Central Nervous System Germ Cell Tumor
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Associated Genetic Biomarkers
Overview
NCI Definition: A germ cell tumor that affects the central nervous system, characterized by the presence of malignant morphologic characteristics. Representative examples include choriocarcinoma, embryonal carcinoma, and germinoma. [1]
Malignant central nervous system germ cell tumors most frequently harbor alterations in KRAS, CDKN1B, H3F3C, CCND2, and PIK3C2G [2].
CDKN1B Amplification, KRAS Amplification, H3F3C Amplification, CCND2 Amplification, and PIK3C2G Amplification are the most common alterations in malignant central nervous system germ cell tumor [2].
Significant Genes in Malignant Central Nervous System Germ Cell Tumor
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.