Associated Genetic Biomarkers

Overview

NCI Definition: A germ cell tumor that affects the central nervous system, characterized by the presence of malignant morphologic characteristics. Representative examples include choriocarcinoma, embryonal carcinoma, and germinoma. [1]

Malignant central nervous system germ cell tumors most frequently harbor alterations in KRAS, CDKN1B, H3F3C, CCND2, and PIK3C2G [2].

Most Commonly Altered Genes in Malignant Central Nervous System Germ Cell Tumor

CDKN1B Amplification, KRAS Amplification, H3F3C Amplification, CCND2 Amplification, and PIK3C2G Amplification are the most common alterations in malignant central nervous system germ cell tumor [2].

Top Alterations in Malignant Central Nervous System Germ Cell Tumor

Significant Genes in Malignant Central Nervous System Germ Cell Tumor

H3F3A +

Disease Details

Synonyms
Malignant Central Nervous System Germ Cell Neoplasm
Parent(s)
Malignant Extragonadal Germ Cell Tumor
Children
Central Nervous System Mixed Germ Cell Tumor, Central Nervous System Teratoma with Malignant Transformation, Central Nervous System Immature Teratoma, Central Nervous System Yolk Sac Tumor, Malignant Intracranial Germ Cell Tumor, Central Nervous System Germinoma, Central Nervous System Embryonal Carcinoma, and Central Nervous System Choriocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.