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Malignant Cervical Neoplasm

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Associated Genetic Biomarkers

Overview

NCI Definition: A primary or metastatic malignant neoplasm involving the cervix. [1]

Malignant cervical neoplasms most frequently harbor alterations in PIK3CA, TP53, KRAS, KMT2D, and ERBB2 [2].

Most Commonly Altered Genes in Malignant Cervical Neoplasm

PIK3CA Mutation, PIK3CA Codon 545 Missense, PIK3CA E545K, TP53 Mutation, and TP53 Missense are the most common alterations in malignant cervical neoplasm [2].

Top Alterations in Malignant Cervical Neoplasm

Clinical Trials

View Clinical Trials for Malignant Cervical Neoplasm

Significant Genes in Malignant Cervical Neoplasm

ERBB2 +

Disease Details

Synonyms
Malignant Neoplasm of Uterine Cervix, Malignant Cervical Tumor, Malignant Tumor of the Cervix, Malignant Cervix Uteri Neoplasm, Malignant Tumor of Uterine Cervix, Malignant Tumor of the Uterine Cervix, Malignant Cervix Uteri Tumor, Malignant Tumor of Cervix, Malignant Tumor of Cervix Uteri, Malignant Uterine Cervix Neoplasm, Malignant Neoplasm of the Cervix Uteri, Malignant Cervix Neoplasm, Malignant Uterine Cervix Tumor, Malignant Cervix Tumor, Malignant Neoplasm of Cervix Uteri, Malignant Neoplasm of Cervix, Malignant Neoplasm of the Uterine Cervix, Malignant Neoplasm of the Cervix, Malignant Tumor of the Cervix Uteri
Parent(s)
Malignant Uterine Neoplasm
Children
Cervical Wilms Tumor, Malignant Cervical Soft Tissue Neoplasm, Cervical Melanoma, Cervical Carcinoma, and Malignant Cervical Mixed Epithelial and Mesenchymal Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.