Malignant digestive system neoplasms most frequently harbor alterations in TP53, KRAS, APC, SMAD4, and PIK3CA [2].

Most Commonly Altered Genes in Malignant Digestive System Neoplasm

TP53 Mutation, KRAS Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, and KRAS Exon 2 Mutation are the most common alterations in malignant digestive system neoplasm [2].

Top Alterations in Malignant Digestive System Neoplasm

Significant Genes in Malignant Digestive System Neoplasm


Disease Details

Malignant Solid Tumor
Malignant Hepatobiliary Neoplasm, Malignant Appendix Neoplasm, Malignant Anal Neoplasm, Digestive System Lymphoma, Malignant Intestinal Neoplasm, Malignant Esophagogastric Neoplasm, Digestive System Carcinoma, Digestive System Sarcoma, Malignant Pancreatic Neoplasm, and Malignant Ampulla of Vater Neoplasm


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.