NCI Definition: Primary or metastatic malignant neoplasm involving the endometrium (mucous membrane that lines the endometrial cavity). [1]

Malignant endometrial neoplasms most frequently harbor alterations in PTEN, PIK3CA, TP53, ARID1A, and PIK3R1 [2].

Most Commonly Altered Genes in Malignant Endometrial Neoplasm

PTEN Mutation, PIK3CA Mutation, TP53 Mutation, TP53 Missense, and TP53 c.217-c.1178 Missense are the most common alterations in malignant endometrial neoplasm [2].

Top Alterations in Malignant Endometrial Neoplasm

Significant Genes in Malignant Endometrial Neoplasm


Disease Details

Endometrial Cancer
Malignant Uterine Corpus Neoplasm
Endometrial Carcinoma and Uterine Corpus Endometrial Stromal Sarcoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.