Overview

NCI Definition: Primary or metastatic malignant neoplasm involving the endometrium (mucous membrane that lines the endometrial cavity). [1]

Malignant endometrial neoplasms most frequently harbor alterations in PTEN, PIK3CA, TP53, ARID1A, and PIK3R1 [2].

Most Commonly Altered Genes in Malignant Endometrial Neoplasm

PTEN Mutation, PIK3CA Mutation, TP53 Mutation, TP53 Missense, and TP53 c.217-c.1178 Missense are the most common alterations in malignant endometrial neoplasm [2].

Top Alterations in Malignant Endometrial Neoplasm

Significant Genes in Malignant Endometrial Neoplasm

ERBB2 +

Disease Details

Synonyms
Endometrial Cancer
Parent(s)
Malignant Uterine Corpus Neoplasm
Children
Uterine Corpus Endometrial Stromal Sarcoma and Endometrial Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.