Overview

NCI Definition: A malignant neoplasm that arises from the epithelial cells of the exocrine pancreatic tissue. [1]

Malignant exocrine pancreatic neoplasms most frequently harbor alterations in KRAS, TP53, CDKN2A, SMAD4, and CDKN2B [2].

Most Commonly Altered Genes in Malignant Exocrine Pancreatic Neoplasm

KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, TP53 Mutation, and TP53 Missense are the most common alterations in malignant exocrine pancreatic neoplasm [2].

Top Alterations in Malignant Exocrine Pancreatic Neoplasm

Disease Details

Synonyms
Malignant Neoplasm of Exocrine Pancreas, Malignant Exocrine Pancreas Tumor, Malignant Tumor of Exocrine Pancreas, Malignant Tumor of the Exocrine Pancreas, Malignant Neoplasm of the Exocrine Pancreas
Parent(s)
Pancreatic Exocrine Neoplasm
Children
Pancreatic Mucinous-Cystic Neoplasm with an Associated Invasive Carcinoma, Pancreatoblastoma, Pancreatic Carcinoma, and Solid Pseudopapillary Neoplasm of the Pancreas

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.