Overview

NCI Definition: A primary or metastatic malignant neoplasm that affects the fallopian tube. Representative examples include carcinoma, carcinosarcoma, and leiomyosarcoma. [1]

Malignant fallopian tube neoplasms most frequently harbor alterations in TP53, NOTCH3, CCNE1, BRD4, and SMARCA4 [2].

Most Commonly Altered Genes in Malignant Fallopian Tube Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Exon 8 Mutation, and TP53fs are the most common alterations in malignant fallopian tube neoplasm [2].

Top Alterations in Malignant Fallopian Tube Neoplasm

Disease Details

Parent(s)
Malignant Female Reproductive System Neoplasm
Children
Fallopian Tube Carcinoma, Fallopian Tube Carcinosarcoma, Fallopian Tube Leiomyosarcoma, and Malignant Fallopian Tube Germ Cell Tumor

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.