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Malignant Female Reproductive System Neoplasm

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Associated Genetic Biomarkers

Overview

NCI Definition: A primary or metastatic malignant neoplasm involving the female reproductive system. Representative examples include endometrial carcinoma, cervical carcinoma, ovarian carcinoma, uterine corpus leiomyosarcoma, adenosarcoma, malignant mixed mesodermal (mullerian) tumor, and gestational choriocarcinoma. [1]

Malignant female reproductive system neoplasms most frequently harbor alterations in TP53, PIK3CA, PTEN, ARID1A, and KRAS [2].

Most Commonly Altered Genes in Malignant Female Reproductive System Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, PIK3CA Mutation, and PTEN Mutation are the most common alterations in malignant female reproductive system neoplasm [2].

Top Alterations in Malignant Female Reproductive System Neoplasm

Clinical Trials

View Clinical Trials for Malignant Female Reproductive System Neoplasm

Significant Genes in Malignant Female Reproductive System Neoplasm

ARID1A +

BRAF +

KRAS +

NF1 +

Disease Details

Synonyms
female reproductive organ cancer
Parent(s)
Malignant Reproductive System Neoplasm
Children
Malignant Vulvar/Vaginal Neoplasm, Female Reproductive System Serous Adenocarcinoma, Malignant Fallopian Tube Neoplasm, Female Reproductive System Papillary Adenocarcinoma, Endometrioid Adenocarcinoma, Malignant Placental Neoplasm, Malignant Mixed Mesodermal (Mullerian) Tumor, Malignant Uterine Neoplasm, Malignant Vaginal Neoplasm, Malignant Ovarian Neoplasm, and Endometrioid Stromal Sarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.