Malignant germ cell tumors most frequently harbor alterations in KRAS, CDKN1B, CCND2, ETV6, and RAD52 [2].

Most Commonly Altered Genes in Malignant Germ Cell Tumor

CDKN1B Amplification, KRAS Amplification, CCND2 Amplification, ETV6 Amplification, and RAD52 Amplification are the most common alterations in malignant germ cell tumor [2].

Top Alterations in Malignant Germ Cell Tumor

Significant Genes in Malignant Germ Cell Tumor



Disease Details

Malignant Solid Tumor
Pulmonary Artery Choriocarcinoma, Malignant Extragonadal Germ Cell Tumor, Malignant Teratoma, Germinoma, Malignant Ovarian Germ Cell Tumor, Embryonal Carcinoma, Yolk Sac Tumor, Seminoma, Malignant Testicular Germ Cell Tumor, Malignant Childhood Germ Cell Tumor, Dysgerminoma, Mixed Germ Cell Tumor, and Malignant Fallopian Tube Germ Cell Tumor


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.