Overview

Malignant germ cell tumors most frequently harbor alterations in KRAS, CDKN1B, CCND2, ETV6, and RAD52 [2].

Most Commonly Altered Genes in Malignant Germ Cell Tumor

CDKN1B Amplification, KRAS Amplification, CCND2 Amplification, ETV6 Amplification, and RAD52 Amplification are the most common alterations in malignant germ cell tumor [2].

Top Alterations in Malignant Germ Cell Tumor

Significant Genes in Malignant Germ Cell Tumor

KIT +

PDGFRA +

Disease Details

Parent(s)
Germ Cell Tumor
Children
Malignant Extragonadal Germ Cell Tumor, Embryonal Carcinoma, Malignant Childhood Germ Cell Tumor, Yolk Sac Tumor, Malignant Testicular Germ Cell Tumor, Pulmonary Artery Choriocarcinoma, Seminoma, Germinoma, Malignant Ovarian Germ Cell Tumor, Mixed Germ Cell Tumor, Dysgerminoma, and Mixed Teratoma and Seminoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.