Malignant head and neck neoplasms most frequently harbor alterations in TP53, CDKN2A, PIK3CA, NOTCH1, and KMT2D [2].

Most Commonly Altered Genes in Malignant Head and Neck Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, PIK3CA Mutation, and NOTCH1 Mutation are the most common alterations in malignant head and neck neoplasm [2].

Top Alterations in Malignant Head and Neck Neoplasm

Significant Genes in Malignant Head and Neck Neoplasm


Disease Details

Malignant Solid Tumor
Head and Neck Carcinoma, Malignant Oral Neoplasm, Head and Neck Sarcoma, Paranasal Sinus and Nasal Cavity Cancer, Malignant Salivary Gland Neoplasm, Malignant Laryngeal Neoplasm, Malignant Ear Neoplasm, Mucosal Melanoma of the Head and Neck, Malignant Pharyngeal Neoplasm, and Orbital Cancer


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.