Overview

Malignant hepatobiliary neoplasms most frequently harbor alterations in TP53, ARID1A, CDKN2A, KRAS, and IDH1 [2].

Most Commonly Altered Genes in Malignant Hepatobiliary Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in malignant hepatobiliary neoplasm [2].

Top Alterations in Malignant Hepatobiliary Neoplasm

Significant Genes in Malignant Hepatobiliary Neoplasm

ABL1 +

BRAF +

DDR2 +

EGFR +

EPHA2 +

ERBB2 +

ERBB4 +

FGFR1 +

FGFR2 +

FLT1 +

FLT4 +

FRK +

IDH1 +

KDR +

KIT +

MAPK11 +

PDGFRA +

PDGFRB +

RAF1 +

RET +

TEK +

TRNAK2 +

VEGFA +

VEGFB +

VEGFC +

Disease Details

Parent(s)
Malignant Digestive System Neoplasm
Children
Malignant Gallbladder Neoplasm, Biliary Tract Carcinoma, Malignant Bile Duct Neoplasm, Malignant Extrahepatic Bile Duct Neoplasm, Primary Malignant Liver Neoplasm, and Metastatic Malignant Neoplasm in the Liver

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.