Malignant lung neoplasms most frequently harbor alterations in TP53, KRAS, EGFR, CDKN2A, and STK11 [2].

Most Commonly Altered Genes in Malignant Lung Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KRAS Mutation, and KRAS Exon 2 Mutation are the most common alterations in malignant lung neoplasm [2].

Top Alterations in Malignant Lung Neoplasm

Disease Details

Lung Cancer, Malignant neoplasm of lung, Metastatic lung cancer
Malignant Thoracic Neoplasm
Lung Hilum Cancer, Lung Meningioma, Pulmonary Blastoma, Lung Lymphoma, Pancoast Tumor, Lung Carcinoma, Lung Malignant PEComa, Lung Sarcoma, and Pancoast Syndrome


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.