NCI Definition: An aggressive malignant tumor of the female reproductive system, affecting predominantly elderly menopausal women. The endometrium and ovary are the most common sites of tumor origin. Morphologically, it is a high grade tumor, composed of carcinomatous and sarcomatous elements. [1]

Malignant mixed mesodermal (mullerian) tumors most frequently harbor alterations in TP53, PIK3CA, KRAS, CCNE1, and PTEN [2].

Most Commonly Altered Genes in Malignant Mixed Mesodermal (Mullerian) Tumor

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, PIK3CA Mutation, and TP53 Exon 7 Mutation are the most common alterations in malignant mixed mesodermal (mullerian) tumor [2].

Top Alterations in Malignant Mixed Mesodermal (Mullerian) Tumor

Significant Genes in Malignant Mixed Mesodermal (Mullerian) Tumor



Disease Details

High-grade carcinoma c/w Mullerian primary, Malignant Mixed Mullerian Tumor, Poorly Differentiated Carcinoma c/w Mullerian Primary, Carcinoma c/w Mullerian Primary, MMMT, Carcinoma c/w M\\u00fcllerian primary
Malignant Female Reproductive System Neoplasm
Vaginal Carcinosarcoma, Ovarian Carcinosarcoma, Primary Peritoneal Carcinosarcoma, Fallopian Tube Carcinosarcoma, and Uterine Carcinosarcoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.