Overview

NCI Definition: An aggressive malignant tumor of the female reproductive system, affecting predominantly elderly menopausal women. The endometrium and ovary are the most common sites of tumor origin. Morphologically, it is a high grade tumor, composed of carcinomatous and sarcomatous elements. [1]

Malignant mixed mesodermal (mullerian) tumors most frequently harbor alterations in TP53, CCNE1, KRAS, PIK3CA, and CEBPA [2].

Most Commonly Altered Genes in Malignant Mixed Mesodermal (Mullerian) Tumor

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Nonsense, and TP53 Frameshift are the most common alterations in malignant mixed mesodermal (mullerian) tumor [2].

Top Alterations in Malignant Mixed Mesodermal (Mullerian) Tumor

Significant Genes in Malignant Mixed Mesodermal (Mullerian) Tumor

BRCA1 +

BRCA2 +

ERBB2 +

Disease Details

Synonyms
Malignant Mixed Mullerian Tumor, MMMT
Parent(s)
Endometrioid Tumor
Children
Uterine Carcinosarcoma, Primary Peritoneal Carcinosarcoma, Fallopian Tube Carcinosarcoma, Ovarian Carcinosarcoma, and Vaginal Carcinosarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.