Overview

NCI Definition: An aggressive malignant tumor of the female reproductive system, affecting predominantly elderly menopausal women. The endometrium and ovary are the most common sites of tumor origin. Morphologically, it is a high grade tumor, composed of carcinomatous and sarcomatous elements. [1]

Malignant mixed mesodermal (mullerian) tumors most frequently harbor alterations in TP53, PIK3CA, KRAS, CCNE1, and PTEN [2].

Most Commonly Altered Genes in Malignant Mixed Mesodermal (Mullerian) Tumor

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, PIK3CA Mutation, and TP53 Exon 7 Mutation are the most common alterations in malignant mixed mesodermal (mullerian) tumor [2].

Top Alterations in Malignant Mixed Mesodermal (Mullerian) Tumor

Significant Genes in Malignant Mixed Mesodermal (Mullerian) Tumor

BRCA1 +

BRCA2 +

Disease Details

Synonyms
Carcinoma c/w M\\u00fcllerian primary, Carcinoma c/w Mullerian Primary, High-grade carcinoma c/w Mullerian primary, Poorly Differentiated Carcinoma c/w Mullerian Primary, MMMT, Malignant Mixed Mullerian Tumor
Parent(s)
Malignant Female Reproductive System Neoplasm
Children
Uterine Carcinosarcoma, Ovarian Carcinosarcoma, Vaginal Carcinosarcoma, Fallopian Tube Carcinosarcoma, and Primary Peritoneal Carcinosarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.