NCI Definition: An infiltrating malignant tumor characterized by the presence of atypical cells with myoepithelial differentiation. Representative examples include malignant breast myoepithelioma and salivary gland myoepithelial carcinoma. 
Malignant myoepitheliomas most frequently harbor alterations in CDKN2A, EWSR1, TP53, SMARCB1, and CDKN2B .
EWSR1 Fusion, CDKN2B Loss, CDKN2A Loss, TP53 c.217-c.1178 Missense, and TP53 Mutation are the most common alterations in malignant myoepithelioma .
There is 1 clinical trial for malignant myoepithelioma, of which 1 is open and 0 are completed or closed. Of the trial that contains malignant myoepithelioma as an inclusion criterion, 1 is phase 2 (1 open).
Nilotinib and paclitaxel are the most common interventions in malignant myoepithelioma clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.