NCI Definition: An infiltrating malignant tumor characterized by the presence of atypical cells with myoepithelial differentiation. Representative examples include malignant breast myoepithelioma and salivary gland myoepithelial carcinoma. [1]

Malignant myoepitheliomas most frequently harbor alterations in CDKN2A, EWSR1, TP53, SMARCB1, and CDKN2B [2].

Most Commonly Altered Genes in Malignant Myoepithelioma

EWSR1 Fusion, CDKN2B Loss, CDKN2A Loss, TP53 c.217-c.1178 Missense, and TP53 Mutation are the most common alterations in malignant myoepithelioma [2].

Top Alterations in Malignant Myoepithelioma

Disease Details

Myoepithelial Carcinoma, MYOEPITHELIOMA, MALIGNANT
Soft Tissue Neoplasm
Soft Tissue Myoepithelial Carcinoma, Salivary Gland Myoepithelial Carcinoma, and Malignant Breast Myoepithelioma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.