Malignant neoplasms most frequently harbor alterations in TP53, CDKN2A, NF1, CDKN2B, and SMARCA4 [2].

Most Commonly Altered Genes in Malignant Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in malignant neoplasm [2].

Top Alterations in Malignant Neoplasm

Significant Genes in Malignant Neoplasm


Disease Details

Cell Type Cancer
Secondary Malignant Neoplasm, Malignant Skin Neoplasm, Virus-Related Lymphoma, Immunodeficiency-Related Malignant Neoplasm, Plasmacytoma, Therapy-Related Malignant Neoplasm, Malignant Soft Tissue Neoplasm, and Undifferentiated Malignant Neoplasm


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.