NCI Definition: An invasive malignant neoplasm that arises from the ovary and is characterized by a predominance of clear and hobnail malignant epithelial cells. [1]

Malignant ovarian clear cell tumors most frequently harbor alterations in ARID1A, PIK3CA, TP53, PPP2R1A, and ARID1B [2].

Most Commonly Altered Genes in Malignant Ovarian Clear Cell Tumor

ARID1A Mutation, PIK3CA Mutation, ARID1A Frameshift, ARID1A Nonsense, and TP53 Mutation are the most common alterations in malignant ovarian clear cell tumor [2].

Top Alterations in Malignant Ovarian Clear Cell Tumor

Significant Genes in Malignant Ovarian Clear Cell Tumor




MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

Disease Details

Malignant Ovarian Clear Cell Neoplasm
Malignant Ovarian Epithelial Tumor
Ovarian Clear Cell Adenocarcinoma and Ovarian Clear Cell Adenocarcinofibroma
OncoTree Name
Clear Cell Ovarian Cancer
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.