Overview

NCI Definition: An invasive malignant neoplasm that arises from the ovary characterized by the presence of malignant, endometrial-type cells. It includes endometrioid adenocarcinoma and carcinosarcoma. [1]

Malignant ovarian endometrioid tumors most frequently harbor alterations in TP53, PIK3CA, KRAS, PTEN, and ARID1A [2].

Most Commonly Altered Genes in Malignant Ovarian Endometrioid Tumor

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, PIK3CA Mutation, and PTEN Mutation are the most common alterations in malignant ovarian endometrioid tumor [2].

Top Alterations in Malignant Ovarian Endometrioid Tumor

Significant Genes in Malignant Ovarian Endometrioid Tumor

ARID1A +

ERBB2 +

KDM6A +

KMT2C +

KMT2D +

SMARCA2 +

SMARCA4 +

SMARCB1 +

SS18 +

SSX1 +

SSX2 +

SSX2B +

SSX4 +

Disease Details

Parent(s)
Ovarian Endometrioid Tumor
Children
Ovarian Carcinosarcoma and Ovarian Endometrioid Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.