Diseases /
Malignant Ovarian Epithelial Tumor
Back to Diseases List
Associated Genetic Biomarkers
Overview
NCI Definition: An invasive malignant tumor that originates from the surface epithelium of the ovary. It is composed of malignant epithelial cells and stroma. Representative examples include serous adenocarcinoma, mucinous adenocarcinoma, endometrioid adenocarcinoma, clear cell adenocarcinoma, and malignant Brenner tumor. [1]
Malignant ovarian epithelial tumors most frequently harbor alterations in TP53, KRAS, PIK3CA, ARID1A, and CCNE1 [2].
TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, TP53 Exon 5 Mutation, and TP53 Exon 8 Mutation are the most common alterations in malignant ovarian epithelial tumor [2].
Clinical Trials
Significant Genes in Malignant Ovarian Epithelial Tumor
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.