Associated Genetic Biomarkers

Overview

NCI Definition: An invasive malignant neoplasm that arises from the ovary and originates from primordial germ cells. Representative examples include embryonal carcinoma, yolk sac tumor, dysgerminoma, and non-gestational choriocarcinoma. [1]

Malignant ovarian germ cell tumors most frequently harbor alterations in PIK3CD, KRAS, TP53, TNFRSF14, and SPEN [2].

Most Commonly Altered Genes in Malignant Ovarian Germ Cell Tumor

TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, KRAS Mutation, and TP53 Exon 7 Mutation are the most common alterations in malignant ovarian germ cell tumor [2].

Top Alterations in Malignant Ovarian Germ Cell Tumor

Disease Details

Synonyms
Ovarian Germ Cell Cancer, Malignant Germ Cell Tumor of the Ovary, Malignant Germ Cell Neoplasm of Ovary, Malignant Ovarian Germ Cell Neoplasm, Malignant Germ Cell Neoplasm of the Ovary, Malignant Germ Cell Tumor of Ovary
Parent(s)
Ovarian Germ Cell Tumor
Children
Immature Ovarian Teratoma, Malignant Struma Ovarii, Childhood Malignant Ovarian Germ Cell Tumor, and Ovarian Primitive Germ Cell Tumor

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.