Overview

NCI Definition: A malignant mixed epithelial neoplasm that arises from the ovary and is composed predominantly of serous and endocervical-type mucinous epithelium. [1]

Malignant ovarian mixed epithelial tumors most frequently harbor alterations in TP53, PIK3CA, KRAS, and KMT2D [2].

Most Commonly Altered Genes in Malignant Ovarian Mixed Epithelial Tumor

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, PIK3CA Mutation, and KRAS Mutation are the most common alterations in malignant ovarian mixed epithelial tumor [2].

Top Alterations in Malignant Ovarian Mixed Epithelial Tumor

Significant Genes in Malignant Ovarian Mixed Epithelial Tumor

BRCA1 +

BRCA2 +

Disease Details

Synonyms
Mixed Epithelial Carcinoma of the Ovary, Malignant Ovarian Mixed Epithelial Neoplasm, Ovarian Seromucinous Carcinoma, Ovarian Mixed Epithelial Carcinoma, Mixed Epithelial Carcinoma of Ovary
Parent(s)
Ovarian Mixed Epithelial Tumor
Children
Ovarian Seromucinous Carcinoma
OncoTree Name
Mixed Ovarian Carcinoma
OncoTree Code
MXOV

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.