NCI Definition: A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas. [1]

Biomarker-Directed Therapies

Significant Genes in Malignant Ovarian Neoplasm



MLH1 +

MSH2 +

MSH6 +

PMS2 +

Disease Details

Malignant Neoplasm of the Ovary, Ovarian Cancer, Malignant Ovarian Tumor, Cancer of the Ovary, Malignant Tumor of the Ovary
Ovarian Neoplasm
Malignant Ovarian Neoplasm, NOS, Ovarian Wilms Tumor, Ovarian Lymphoma, Malignant Ovarian Epithelial Tumor, Ovarian Malignant Mesothelioma, Ovarian Sarcoma, Malignant Ovarian Cyst, and Ovarian Choriocarcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.