Overview

NCI Definition: A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas. [1]

Malignant ovarian neoplasms most frequently harbor alterations in TP53, KRAS, PIK3CA, ARID1A, and CCNE1 [2].

Most Commonly Altered Genes in Malignant Ovarian Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, TP53 Frameshift, and TP53 Nonsense are the most common alterations in malignant ovarian neoplasm [2].

Top Alterations in Malignant Ovarian Neoplasm

Biomarker-Directed Therapies

Significant Genes in Malignant Ovarian Neoplasm

BRCA1 +

BRCA2 +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

Disease Details

Synonyms
Malignant Tumor of the Ovary, Malignant Ovarian Tumor, Malignant Neoplasm of the Ovary, Cancer of the Ovary, Ovarian Cancer
Parent(s)
Ovarian Neoplasm
Children
Ovarian Lymphoma, Ovarian Choriocarcinoma, Krukenberg Tumor, Malignant Ovarian Epithelial Tumor, Ovarian Wilms Tumor, Malignant Ovarian Neoplasm, NOS, Ovarian Malignant Mesothelioma, Malignant Ovarian Cyst, and Ovarian Sarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.