Overview

NCI Definition: An invasive malignant neoplasm that arises from the ovary and is characterized by the presence of malignant epithelial cells that, in well differentiated tumors, resemble the epithelium of the fallopian tube or, in poorly differentiated tumors, show anaplastic features and marked nuclear atypia. It includes serous adenocarcinoma and serous adenocarcinofibroma. [1]

Malignant ovarian serous tumors most frequently harbor alterations in TP53, KRAS, CCNE1, BRCA1, and NF1 [2].

Most Commonly Altered Genes in Malignant Ovarian Serous Tumor

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, TP53 Frameshift, and TP53 Nonsense are the most common alterations in malignant ovarian serous tumor [2].

Top Alterations in Malignant Ovarian Serous Tumor

Significant Genes in Malignant Ovarian Serous Tumor

BRCA1 +

BRCA2 +

Disease Details

Parent(s)
Malignant Ovarian Epithelial Tumor
Children
Ovarian Serous Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.