Overview

NCI Definition: A primary or metastatic malignant neoplasm involving the peritoneum. Representative examples include carcinoma and malignant mesothelioma. [1]

Malignant peritoneal neoplasms most frequently harbor alterations in TP53, KRAS, EPHB1, BRCA2, and BCOR [2].

Most Commonly Altered Genes in Malignant Peritoneal Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53fs, and TP53 Exon 8 Mutation are the most common alterations in malignant peritoneal neoplasm [2].

Top Alterations in Malignant Peritoneal Neoplasm

Significant Genes in Malignant Peritoneal Neoplasm

BRCA1 +

BRCA2 +

Disease Details

Parent(s)
Peritoneal Neoplasm
Children
Peritoneal Carcinomatosis, Malignant Peritoneal Solitary Fibrous Tumor, Primary Peritoneal Carcinoma, Peritoneal Malignant Mesothelioma, Malignant Peritoneal Germ Cell Tumor, and Primary Peritoneal Carcinosarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.