Malignant pleural mesotheliomas most frequently harbor alterations in BAP1, NF2, CDKN2A, CDKN2B, and TP53 [2].

Most Commonly Altered Genes in Malignant Pleural Mesothelioma

CDKN2A Loss, CDKN2B Loss, BAP1 Mutation, BAP1fs, and NF2 Mutation are the most common alterations in malignant pleural mesothelioma [2].

Top Alterations in Malignant Pleural Mesothelioma

Significant Genes in Malignant Pleural Mesothelioma

NF2 +

Disease Details

Pleural Mesothelioma
Lymphohistiocytoid Mesothelioma, Pleural Epithelioid Mesothelioma, Pleural Mesothelioma, Sarcomatoid Type, and Pleural Biphasic Mesothelioma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.