Malignant Pleural Neoplasm
NCI Definition: A primary or metastatic malignant neoplasm affecting the pleura. A representative example of primary malignant pleural neoplasm is the malignant pleural mesothelioma. A representative example of metastatic malignant neoplasm to the pleura is metastatic carcinoma that has spread to the pleura from another anatomic site. 
Malignant pleural neoplasms most frequently harbor alterations in DICER1, TP53, RECQL4, OGG1, and MUS81 .
DICER1fs, DICER1 Mutation, TP53 c.217-c.1178 Missense, TP53 R273C, and TP53 Mutation are the most common alterations in malignant pleural neoplasm .
There is 1 clinical trial for malignant pleural neoplasm, of which 0 are open and 1 is completed or closed. Of the trial that contains malignant pleural neoplasm as an inclusion criterion, 1 is phase 1/phase 2 (0 open).
Nivolumab and talimogene laherparepvec are the most common interventions in malignant pleural neoplasm clinical trials.
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.