NCI Definition: A primary or metastatic malignant neoplasm affecting the pleura. A representative example of primary malignant pleural neoplasm is the malignant pleural mesothelioma. A representative example of metastatic malignant neoplasm to the pleura is metastatic carcinoma that has spread to the pleura from another anatomic site. [1]

Malignant pleural neoplasms most frequently harbor alterations in DICER1, TP53, RECQL4, OGG1, and MUS81 [2].

Most Commonly Altered Genes in Malignant Pleural Neoplasm

DICER1fs, DICER1 Mutation, TP53 c.217-c.1178 Missense, TP53 R273C, and TP53 Mutation are the most common alterations in malignant pleural neoplasm [2].

Top Alterations in Malignant Pleural Neoplasm

Disease Details

Cancer of the Pleura, Cancer of Pleura, Malignant Neoplasm of the Pleura, Malignant Tumor of the Pleura, Malignant Neoplasm of Pleura, Malignant Pleural Tumor, Malignant Tumor of Pleura, Pleural Cancer
Pleural Neoplasm
Malignant Pleural Mesothelioma and Pleuropulmonary Blastoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.