Diseases /
Malignant Pleural Neoplasm
Overview
NCI Definition: A primary or metastatic malignant neoplasm affecting the pleura. A representative example of primary malignant pleural neoplasm is the malignant pleural mesothelioma. A representative example of metastatic malignant neoplasm to the pleura is metastatic carcinoma that has spread to the pleura from another anatomic site. [1]
Malignant pleural neoplasms most frequently harbor alterations in DICER1, TP53, RECQL4, OGG1, and MUS81 [2].
DICER1fs, DICER1 Mutation, TP53 c.217-c.1178 Missense, TP53 R273C, and TP53 Mutation are the most common alterations in malignant pleural neoplasm [2].
Clinical Trials
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.