NCI Definition: A malignant neoplasm that arises from the brain. Representative examples include anaplastic astrocytoma, glioblastoma, and lymphoma. [1]

Malignant primary brain neoplasms most frequently harbor alterations in TP53, NRAS, MTOR, FBXW7, and CDKN2A [2].

Most Commonly Altered Genes in Malignant Primary Brain Neoplasm

TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, TP53 Exon 7 Mutation, and NRAS Mutation are the most common alterations in malignant primary brain neoplasm [2].

Top Alterations in Malignant Primary Brain Neoplasm

Significant Genes in Malignant Primary Brain Neoplasm

H3F3A +

Disease Details

Malignant Primary Brain Tumor
Primary Brain Neoplasm
Cerebral Lymphoma and Brain Glioblastoma
OncoTree Name
Malignant Tumor
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.