Malignant Primary Brain Neoplasm
NCI Definition: A malignant neoplasm that arises from the brain. Representative examples include anaplastic astrocytoma, glioblastoma, and lymphoma. 
Malignant primary brain neoplasms most frequently harbor alterations in TP53, NRAS, MTOR, FBXW7, and CDKN2A .
TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, TP53 Exon 7 Mutation, and NRAS Mutation are the most common alterations in malignant primary brain neoplasm .
There is 1 clinical trial for malignant primary brain neoplasm, of which 1 is open and 0 are completed or closed. Of the trial that contains malignant primary brain neoplasm as an inclusion criterion, 1 is phase 1 (1 open).
Onc206 is the most common intervention in malignant primary brain neoplasm clinical trials.
Significant Genes in Malignant Primary Brain Neoplasm
H3F3A is an inclusion eligibility criterion in 1 clinical trial for malignant primary brain neoplasm, of which 1 is open and 0 are closed. Of the trial that contains H3F3A status and malignant primary brain neoplasm as inclusion criteria, 1 is phase 1 (1 open) .
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.