Overview

NCI Definition: A malignant neoplasm that arises from the brain. Representative examples include anaplastic astrocytoma, glioblastoma, and lymphoma. [1]

Malignant primary brain neoplasms most frequently harbor alterations in TP53, NRAS, MTOR, FBXW7, and CDKN2A [2].

Most Commonly Altered Genes in Malignant Primary Brain Neoplasm

TP53 c.217-c.1178 Missense, TP53 Mutation, TP53 Missense, TP53 Exon 7 Mutation, and NRAS Mutation are the most common alterations in malignant primary brain neoplasm [2].

Top Alterations in Malignant Primary Brain Neoplasm

Significant Genes in Malignant Primary Brain Neoplasm

H3F3A +

Disease Details

Synonyms
Malignant Primary Brain Tumor
Parent(s)
Primary Brain Neoplasm
Children
Brain Glioblastoma and Cerebral Lymphoma
OncoTree Name
Malignant Tumor
OncoTree Code
MT

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.