Malignant reproductive system neoplasms most frequently harbor alterations in TP53, PTEN, PIK3CA, ARID1A, and KRAS [2].

Most Commonly Altered Genes in Malignant Reproductive System Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, PIK3CA Mutation, and PTEN Mutation are the most common alterations in malignant reproductive system neoplasm [2].

Top Alterations in Malignant Reproductive System Neoplasm

Disease Details

Reproductive System Neoplasm
Uterine Ligament Cancer, Rete Ovarii Adenocarcinoma, Malignant Male Reproductive System Neoplasm, Sex Cord-Stromal Tumor, Malignant Female Reproductive System Neoplasm, and Placenta Cancer


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.