NCI Definition: A primary or metastatic tumor involving the skin. Primary malignant skin tumors most often are carcinomas (either basal cell or squamous cell carcinomas that arise from cells in the epidermis) or melanomas that arise from pigment-containing skin melanocytes. Metastatic tumors to the skin include carcinomas and lymphomas. [1]

Malignant skin neoplasms most frequently harbor alterations in BRAF, TP53, CDKN2A, NRAS, and KMT2D [2].

Most Commonly Altered Genes in Malignant Skin Neoplasm

BRAF Mutation, BRAF Exon 15 Mutation, TP53 Mutation, BRAF Codon 600 Missense, and TP53 Missense are the most common alterations in malignant skin neoplasm [2].

Top Alterations in Malignant Skin Neoplasm

Disease Details

Malignant Tumor of the Skin, Melanoma and Non-Melanoma Skin Cancer, Malignant Tumor of Skin, Malignant Neoplasm of Skin, Skin Neoplasm, Malignant, Malignant Neoplasm of the Skin, Malignant Skin Tumor, Skin Cancer, Including Melanoma, Skin cancer, NOS, Skin Cancer
Skin Neoplasm
Atypical Fibroxanthoma, Blastic Plasmacytoid Dendritic Cell Neoplasm, Malignant Skin Appendage Neoplasm, Skin Carcinoma, Cutaneous Melanoma, Cutaneous Lymphoma, Malignant Dermal Neoplasm, and Malignant Scrotal Neoplasm


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.