NCI Definition: A primary or metastatic tumor involving the skin. Primary malignant skin tumors most often are carcinomas (either basal cell or squamous cell carcinomas that arise from cells in the epidermis) or melanomas that arise from pigment-containing skin melanocytes. Metastatic tumors to the skin include carcinomas and lymphomas. [1]

Malignant skin neoplasms most frequently harbor alterations in BRAF, TP53, CDKN2A, NRAS, and KMT2D [2].

Most Commonly Altered Genes in Malignant Skin Neoplasm

BRAF Mutation, BRAF Exon 15 Mutation, TP53 Mutation, BRAF Codon 600 Missense, and TP53 Missense are the most common alterations in malignant skin neoplasm [2].

Top Alterations in Malignant Skin Neoplasm

Disease Details

Skin cancer, NOS, Malignant Tumor of Skin, Skin Cancer, Including Melanoma, Skin Cancer, Malignant Tumor of the Skin, Malignant Skin Tumor, Skin Neoplasm, Malignant, Malignant Neoplasm of the Skin, Malignant Neoplasm of Skin, Melanoma and Non-Melanoma Skin Cancer
Skin Neoplasm
Malignant Sebaceous Neoplasm, Skin Carcinoma, Blastic Plasmacytoid Dendritic Cell Neoplasm, Cutaneous Melanoma, Malignant Granular Cell Tumor, Malignant Sweat Gland Neoplasm, Atypical Fibroxanthoma, Malignant Scrotal Neoplasm, and Malignant Dermal Neoplasm


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.