NCI Definition: A primary or metastatic tumor involving the skin. Primary malignant skin tumors most often are carcinomas (either basal cell or squamous cell carcinomas that arise from cells in the epidermis) or melanomas that arise from pigment-containing skin melanocytes. Metastatic tumors to the skin include carcinomas and lymphomas. [1]

Malignant skin neoplasms most frequently harbor alterations in BRAF, TP53, CDKN2A, NRAS, and KMT2D [2].

Most Commonly Altered Genes in Malignant Skin Neoplasm

BRAF Mutation, TP53 Mutation, BRAF Exon 15 Mutation, BRAF Codon 600 Missense, and TP53 Missense are the most common alterations in malignant skin neoplasm [2].

Top Alterations in Malignant Skin Neoplasm

Disease Details

Skin Cancer, Including Melanoma, Skin Neoplasm, Malignant, Malignant Neoplasm of the Skin, Melanoma and Non-Melanoma Skin Cancer, Malignant Skin Tumor, Skin Cancer, Malignant Neoplasm of Skin, Malignant Tumor of Skin, Skin cancer, NOS, Malignant Tumor of the Skin
Skin Neoplasm
Malignant Granular Cell Tumor, Malignant Dermal Neoplasm, Skin Carcinoma, Cutaneous Melanoma, Malignant Sweat Gland Neoplasm, Atypical Fibroxanthoma, Malignant Scrotal Neoplasm, Blastic Plasmacytoid Dendritic Cell Neoplasm, and Malignant Sebaceous Neoplasm


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.