Overview

NCI Definition: A malignant neoplasm arising exclusively from the soft tissues. [1]

Malignant soft tissue neoplasms most frequently harbor alterations in KIT, TP53, CDKN2A, CDKN2B, and RB1 [2].

Most Commonly Altered Genes in Malignant Soft Tissue Neoplasm

KIT Mutation, KIT Exon 11 Mutation, KIT Deletion, KIT Exon 11 Deletion, and TP53 Mutation are the most common alterations in malignant soft tissue neoplasm [2].

Top Alterations in Malignant Soft Tissue Neoplasm

Disease Details

Synonyms
Malignant Neoplasm of the Soft Tissue, Malignant Tumor of Soft Tissue, Malignant Tumor of the Soft Tissue, Malignant Soft Tissue Tumor, Malignant Neoplasm of Soft Tissue
Parent(s)
Soft Tissue Neoplasm
Children
Malignant Synovial Neoplasm, Extrarenal Rhabdoid Tumor, Malignant Cervical Soft Tissue Neoplasm, Soft Tissue Sarcoma, and Malignant Pericytic Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.