Malignant supratentorial neoplasms most frequently harbor alterations in EPHB1, DICER1, CDK12, ATR, and ATM [2].

Most Commonly Altered Genes in Malignant Supratentorial Neoplasm

EPHB1 V205E, EPHB1 Mutation, CDK12 P1091S, CDK12 Mutation, and ATR Mutation are the most common alterations in malignant supratentorial neoplasm [2].

Top Alterations in Malignant Supratentorial Neoplasm

Significant Genes in Malignant Supratentorial Neoplasm


Disease Details

Suprantentorial Neoplasms, Malignant, Supratentorial Cancer, Malignant Supratentorial Tumor
Malignant Brain Neoplasm
Supratentorial Primitive Neuroectodermal Tumor, Malignant Pineal Region Neoplasm, Malignant Cerebral Neoplasm, Childhood Supratentorial Ependymoma, and Childhood Cerebral Ependymoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.