Overview

Malignant testicular neoplasms most frequently harbor alterations in KRAS, CDKN1B, CCND2, ETV6, and RAD52 [2].

Most Commonly Altered Genes in Malignant Testicular Neoplasm

CDKN1B Amplification, CCND2 Amplification, ETV6 Amplification, KRAS Amplification, and RAD52 Amplification are the most common alterations in malignant testicular neoplasm [2].

Top Alterations in Malignant Testicular Neoplasm

Significant Genes in Malignant Testicular Neoplasm

KRAS +

TP53 +

Disease Details

Parent(s)
Testicular Neoplasm
Children
Testicular Germ Cell Tumor, Testicular Lymphoma, Malignant Testicular Germ Cell Tumor, Childhood Testicular Neoplasm, Epididymal Neoplasm, Testicular Brenner Tumor, Testicular Sarcoma, and Testicular Leukemia

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.