Overview

Malignant testicular neoplasms most frequently harbor alterations in KRAS, CDKN1B, ETV6, CCND2, and RAD52 [2].

Most Commonly Altered Genes in Malignant Testicular Neoplasm

CDKN1B Amplification, CCND2 Amplification, ETV6 Amplification, RAD52 Amplification, and KRAS Amplification are the most common alterations in malignant testicular neoplasm [2].

Top Alterations in Malignant Testicular Neoplasm

Significant Genes in Malignant Testicular Neoplasm

KRAS +

TP53 +

Disease Details

Parent(s)
Testicular Neoplasm
Children
Testicular Leukemia, Epididymal Neoplasm, Childhood Testicular Neoplasm, Malignant Testicular Germ Cell Tumor, Testicular Germ Cell Tumor, Testicular Brenner Tumor, Testicular Lymphoma, and Testicular Sarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.